A nextflow pipeline for molecular quantitative trait loci mapping in small sample size datasets with an application in Atlantic salmon

Dat Thanh Nguyen; Simen R. Sandve; Sigbjørn Lien; Lars Grønvold; Dat Thanh Nguyen; Simen R. Sandve; Sigbjørn Lien; Lars Grønvold

doi:10.1186/s12864-025-12302-5

November 20, 2025BMC GenomicsOpen Access

A nextflow pipeline for molecular quantitative trait loci mapping in small sample size datasets with an application in Atlantic salmon

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Key Points

To develop a nextflow pipeline for mapping molecular quantitative trait loci in small sample datasets, with a focus on Atlantic salmon.
Utilized a nextflow pipeline to facilitate molecular quantitative trait loci mapping.
Applied the pipeline to datasets from Atlantic salmon to demonstrate its utility.
Focused on small sample sizes to validate the scalability of the method.
Demonstrated the scalability of the nf-RASQUAL pipeline for molecular quantitative trait loci studies.
Facilitated genetic regulation research in aquaculture through successful application in Atlantic salmon.
Improved understanding of how genetic diversity shapes molecular phenotypes.

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Implication

A nextflow pipeline enhances molecular quantitative trait loci mapping in aquaculture species, suggesting advances in genetic regulation research.

Abstract

These findings highlight the scalability and utility of nf-RASQUAL for advancing genetic regulation research in aquaculture, facilitating molQTL studies in less-explored species, and improving our understanding of molecular phenotypes shaped by genetic diversity.

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Cite This Study

Nguyen et al. (2025) studied this question.

synapsesocial.com/papers/6924f07fc0ce034ddc350153 https://doi.org/10.1186/s12864-025-12302-5

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A nextflow pipeline for molecular quantitative trait loci mapping in small sample size datasets with an application in Atlantic salmon

Key Points

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Abstract

Discussion

Cite This Study

A nextflow pipeline for molecular quantitative trait loci mapping in small sample size datasets with an application in Atlantic salmon

Key Points

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Implication

Abstract

Discussion

Cite This Study

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