This trial shows that ketoprofen reduces inflammatory markers and improves insulin resistance in early-lactation cows, indicating metabolic benefits of NSAID treatment.
Key Points
This study aims to explore the relationship between inflammatory parameters and insulin resistance indices in early-lactation cows.
Thirty Holstein–Friesian cows were divided into control and treatment groups.
The treatment group received ketoprofen during the first postpartal week.
Blood samples were taken at three timepoints to analyze inflammatory markers and insulin resistance indices.
Inflammatory markers increased over the first two weeks postpartum in the control group.
Ketoprofen administration reduced inflammatory markers and improved insulin resistance indices.
Positive correlations were found between inflammatory markers and insulin resistance, while negative correlations were with glucose.