Diagnostic Value of miR ‐454‐3p Combined With Color Doppler Ultrasound in Breast Cancer

Purpose To explore the diagnostic value of miR‐454‐3p combined with Color Doppler ultrasonography (CDUS) in BC, hoping to provide new insights for breast cancer (BC) diagnosis. Methods A total of 205 female BC patients, 80 patients with benign breast diseases, and 50 healthy females were recruited. Serum miR‐454‐3p levels were measured by RT‐qPCR, and all subjects underwent ultrasonic examination. Results BC patients had significantly higher rates of irregular morphology, unclear boundaries, spiculations, shadowing, microcalcifications, aspect ratio ≥ 1, and blood flow grades II–III. Blood flow characteristics (RI, PI, and V max ) were also notably elevated in BC compared to benign cases. miR‐454‐3p is significantly upregulated in both benign and BC groups. In BC patients, the expression levels of miR‐454‐3p were significantly elevated in those with larger tumors, higher histological grades, higher TNM stages, tumor lymph node metastasis, positive ER, and positive HER‐2. The expression of miR‐454‐3p in BC patients was significantly correlated with ultrasound boundary, spiculated margins, echogenicity, aspect ratio, blood flow grading, and blood flow characteristics (RI, PI, and V max ). miR‐454‐3p can improve the accuracy of CDUS in diagnosing BC. Conclusion miR‐454‐3p has diagnostic value in BC, and its expression is significantly correlated with tumor deterioration. Combining miR‐454‐3p and CDUS can improve diagnostic accuracy, providing a reference for early clinical diagnosis of BC.