Laboratory study demonstrates hydrostatic pressure alters cell migration and proliferation in lung cancer cells, suggesting a role in tumor progression.
The tumor microenvironment contributes to tumorigenesis and tumor progression. Interstitial fluid pressure is elevated in almost all solid malignant tumors, and physical pressure in the tumor microenvironment influences various cancer cell functions, including cell proliferation. However, the direction of the pressure applied to cancer cells has not been considered in previous studies, and the role of physical pressure in the tumor microenvironment in tumor progression remains unclear. Therefore, we investigated the effects of hydrostatic pressure applied to the basal side on lung cancer cells cultured on Transwell filters. Our data show that hydrostatic pressure from the basal side alters various phenotypes of cancer cells, including cell migration, polarity, proliferation, and cell death, all of which are presumed to contribute to tumor progression. These results suggest that physical pressure in the tumor microenvironment provides cancer cells with an advantage in various phenotypes and plays an important role in cancer cell biology. [Media: see text] [Media: see text] [Media: see text] [Media: see text] [Media: see text] [Media: see text] [Media: see text] [Media: see text] [Media: see text] [Media: see text] [Media: see text] [Media: see text] [Media: see text]
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Onoi et al. (2025) studied this question.
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