Fabrication of Functionalized Alkyne‐Conjugated Chitosan With Bactericidal Efficacy

The development of sugar‐based materials has been a challenging area to cope with the eco‐friendly alternatives to conventional synthetic materials. A semi‐synthetic approach has been designed to form a reactive Schiff base colloidal material, featuring a terminal alkyne functionality within a 3D chitosan‐based matrix with a particle size of 286 nm. Raman spectroscopy shows a prominent 2124 cm −1 for peak, 1680 cm −1 for imine () within bonding‐networks. The formation of this material is confirmed by the 3283 cm −1 peaks in FT‐IR spectroscopy for , and in 3.23 ppm is an indicative peak for in 1 H‐NMR. The finding of reactive alkyne moieties has been captured using the role of a dienophile towards anthracene‐9‐carbaldehyde via Diels–Alder reaction, and forms a triazole moiety for alkyne‐azide coupling through Click reactions. The alkyne‐functionalized sugar colloid is used as an efficient radical scavenger, and its binding affinity with Human Serum Albumin (HSA) demonstrates promising bio‐interactive behavior. It also has antibacterial potency. The sugar material undergoes degradation through common oxidizing agents, confirming its potential as a biodegradable and functional material suitable for biomedical and environmental applications.