Targeting Tris(2,3-dibromopropyl) Isocyanurate-Induced Inflammation in Hippocampal Neurons In Vitro: Mechanistic Insights and Implications for Neurodegenerative Disease Prevention
In vitro experiments highlighted TBC exposure's impact on cellular metabolism in hippocampal neurons, suggesting inflammation may be a key factor in neurotoxic effects.
Key Points
The aim was to investigate the neurotoxic effects of Tris(2,3-dibromopropyl) isocyanurate (TBC) on mouse hippocampal neurons, focusing on its influence on cellular mechanisms.
In vitro analysis of TBC effects on mouse hippocampal cells.
Evaluation of metabolic activity and apoptosis-related caspase activity.
Co-treatment with AhR antagonist, PPARγ antagonist, and NF-κB inhibitor to assess signaling pathway interactions.
Prolonged TBC exposure decreased metabolic activity and increased apoptotic markers in neurons.
TBC increased inflammatory cytokine expression and impaired antioxidant enzyme activity.
Notable alterations in NF-κB signaling pathways and protein expressions were observed.
Cite This Study
Szlachcikowska et al. (2025) studied this question.