What question did this study set out to answer?

The study aims to explore the relationship between spinal cord leptomeningeal enhancement and extensive spinal cord involvement in children with MOGAD.

November 18, 2025Neurology Neuroimmunology & Neuroinflammation1 citationsOpen Access

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Spinal Cord Leptomeningeal Enhancement as a Marker of Extensive Spinal Cord Involvement in Children With MOGAD

SBSerenella BartiromoUniversity of Verona CACesar Alves JOJulia O'Mahony

Key Points

The study aims to explore the relationship between spinal cord leptomeningeal enhancement and extensive spinal cord involvement in children with MOGAD.
Analyzed MRI findings in children with spinal cord abnormalities and MOGAD.
Examined correlation of leptomeningeal enhancement with the extent of spinal cord involvement.
Considered cases of seronegative myelitis for comparative analysis.
Presence of spinal cord leptomeningeal enhancement linked with more extensive spinal cord abnormalities.
Findings suggest clinical significance for diagnosis and treatment in pediatric patients.

Abstract

The presence of spinal cord LME is associated with more extensive spinal cord abnormalities on MRI in children with MOGAD and to a lesser extent in those with seronegative myelitis. The biological underpinnings of this finding and its clinical implications should be assessed in further studies.

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Spinal Cord Leptomeningeal Enhancement as a Marker of Extensive Spinal Cord Involvement in Children With MOGAD

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Abstract

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