The Influevce of the Experimental Model of White Noise, Not Combined With Vibration on Brain Hemodynamics and Brain Oxygen Balance

The noise, as a professional harmfulness, is usually combined with other technogenic factors such asvibration, ultra- and infrasound, motion sickness. Therefore, it is possible to evaluate the isolated effect ofnoise in experimental modeling conditions. Goals. To create a model of isolated influence of white noise on awaking rabbits, the level of which corresponds to professional harmfulness for humans, but does not cause hearing organ damage. T o study the changes in local cerebral blood flow, vascular reactivity and oxygen tension in the brain tissues on the background of these model. Material and methods. A stand using a foamen support for a box with a rabbit and acoustic speakers, which provide the correct modeling of white noise, the intensity of which corresponds to professional industrial harmfulness was created. Electrodes were implanted into the cerebral cortex, hypothalamus, and thalamus of chinchilla rabbits in preparing for chronic experiments. Local blood flow, dilator reactivity of vessels to hypercapnia and constrictor reactivity of blood vessels to hyperoxia were studied by the H2 clearance method. Oxygen tensionwas studied by the polarography method. Results. Measuring the level of white noise using a stand near rabbit’s ears showed that it is professional harmfulness, but does not exceed the maximum permissible values. White noise simulated in this way causes hypoxia of the brain, which leads to an increase in the speed of local blood flow in the brain, and a slowdown in the reaction of vessels, mainly constrictor ones, is also observed. Conclusion. Along with hearing loss, the noise causes a symptom complex of the so-called extraural pathology, including, cerebrovascular disorders,the development of pharmacological correction of which has a scientific and practical interest.