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Combination of methylation, afp protein identifies hepatocellular carcinoma with improved sensitivity and specificity.
This study provides compelling evidence that the combination of RASSF1A/TSPYL5 methylation and AFP protein is a promising biomarker panel for the early detection of HCC. The ARTHCC model demonstrates remarkable sensitivity and specificity, outperforming AFP.
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Chen et al. (2025) studied this question.
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