Synthesis, Characterization, and Antimicrobial Activity of Some New 2,4-Dihydro-3H-1,2,4-Triazole-3-thione Derivatives

Fatih TOK; Damla DAMAR ÇELİK

doi:10.4274/tjps.galenos.2025.77834

November 18, 2025Turkish Journal of Pharmaceutical SciencesOpen Access

Synthesis, Characterization, and Antimicrobial Activity of Some New 2,4-Dihydro-3H-1,2,4-Triazole-3-thione Derivatives

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Key Points

Significant antimicrobial activity observed against Gram-positive bacteria and fungi, including E. faecalis and Candida strains.
The antimicrobial activity was particularly pronounced for compound T6, highlighting its effectiveness.
Synthesis of 2,4-Dihydro-3H-1,2,4-Triazole-3-thione derivatives involved various chemical characterization techniques.
Further studies are necessary to explore clinical implications and optimize formulations for therapeutic use.

Implication

Chemical synthesis shows antimicrobial activity against gram-positive bacteria, indicating potential medical uses.

Abstract

Among the compounds, T6 appears to exhibit significant antimicrobial activity against both Gram-positive bacteria (e.g., E. faecalis ATCC 29212 and S. epidermidis ATCC 12228) and fungi (e.g., Candida strains).

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Cite This Study

TOK et al. (2025) studied this question.

synapsesocial.com/papers/6924fef9c0ce034ddc351e35 https://doi.org/10.4274/tjps.galenos.2025.77834

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Synthesis, Characterization, and Antimicrobial Activity of Some New 2,4-Dihydro-3H-1,2,4-Triazole-3-thione Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

Synthesis, Characterization, and Antimicrobial Activity of Some New 2,4-Dihydro-3H-1,2,4-Triazole-3-thione Derivatives

Key Points

Implication

Abstract

Discussion

Cite This Study

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