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Research demonstrates increased c-Fos expression in neurons during chronic intermittent hypoxia, indicating the Paraventricular nucleus plays a role in respiratory control.
A direct relationship exists between the PVN and preBötC. CIH increased c-Fos expression in respiratory-related nuclei, including the PVN. Modulating the PVN activity impacts MV by adjusting the RF; without influencing arterial blood gas levels. The PVN is probably involved in respiratory control via the PVN-preBötC circuit.
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Liu et al. (2025) studied this question.
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