CPAP therapy reduces systemic inflammation and immune dysregulation in obstructive sleep apnea, implying significant immune modulation related to hypoxic indices.
CPAP alleviates systemic inflammation in OSA by reducing hypoxic burden and reprogramming monocytes toward an anti-inflammatory phenotype. The magnitude of immune modulation was more closely linked to ODI than AHI, suggesting that oxygen desaturation burden serves as meaningful adjuncts to AHI in assessing monocyte-driven immune dysregulation in OSA.
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Hong et al. (2025) studied this question.
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