Predictive Utility of Genetic Risk for Myopic Maculopathy Presence and Progression in a Chinese High Myopia Cohort

Zhixi Li; Ziyi Zhao; Kai Zhang; Feng Jiang; Liqiong Xie; Mingguang He

doi:10.1167/iovs.66.14.38

November 17, 2025Investigative Ophthalmology & Visual ScienceOpen Access

Predictive Utility of Genetic Risk for Myopic Maculopathy Presence and Progression in a Chinese High Myopia Cohort

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Key Points

This research aims to assess the predictive utility of genetic risk for myopic maculopathy in a cohort with high myopia.
Analyzed genetic risk factors using a cohort of Chinese high myopia patients.
Examined the presence and progression of myopic maculopathy in both pediatric and adult populations.
Compared the predictive ability of genetic risk scores to conventional prediction methods.
Genetic risk factors alone do not effectively predict myopic maculopathy.
The addition of genetic risk factors offers limited enhancement to prediction performance.

Implication

Findings show genetic risk does not predict myopic maculopathy in high myopia cohorts, indicating limited value in conventional predictors.

Abstract

The PRS alone fails to predict myopic maculopathy among Chinese highly myopic pediatric and adult populations, and the enhancement in prediction performance is quite limited when it is added to conventional predictors.

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Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/692509e8c0ce034ddc3527b7 https://doi.org/10.1167/iovs.66.14.38

View Full Paper

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Predictive Utility of Genetic Risk for Myopic Maculopathy Presence and Progression in a Chinese High Myopia Cohort

Key Points

Implication

Abstract

Discussion

Cite This Study

Predictive Utility of Genetic Risk for Myopic Maculopathy Presence and Progression in a Chinese High Myopia Cohort

Key Points

Implication

Abstract

Discussion

Cite This Study

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