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Murine model demonstrates sexual dimorphism and alters colonization of Staphylococcus aureus in the gastrointestinal tract, suggesting key infection mechanisms.
We developed a robust murine model for antibiotic-associated S. aureus gastrointestinal infection and colonization. This model shows both sexual dimorphism and macronutrient preference for SAGII signs severity. Diet manipulation can also be used to establish S. aureus colonization of the GI tract. Furthermore, the SAGII murine model demonstrates essential features of S. aureus pathogenesis which could provide understanding about human gastrointestinal colonization and infection mechanisms.
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Niamba et al. (2025) studied this question.
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