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November 17, 2025Blood Cancer JournalOpen Access

A superantigen-based MHC class II-targeted cancer immunotherapy for the treatment of acute myeloid leukemia

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Authors

LGLena GolickRRReeder M. RobinsonLRLeticia Reyes

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Overview

Immunotherapy induced an immune response against acute myeloid leukemia, suggesting its preclinical potential in treatment.

Key Points

  • The study aims to develop an immunotherapy targeting CD33 in acute myeloid leukemia (AML).
  • Developed M2T-CD33 to target CD33 on MHC class II
  • Evaluated the immune response in a syngeneic mouse model
  • Assessed the effect of combining M2T-CD33 with anti-PD-1 therapy
  • M2T-CD33 induced a robust polyclonal anti-CD33 humoral response
  • Elicited an anti-AML immune response dependent on CD4+ and CD8+ T cells
  • Showed no toxicity at doses 40-fold higher than efficacious levels
  • Demonstrated preclinical efficacy and potential with combined therapies.

Cite This Study

Golick et al. (2025) studied this question.

synapsesocial.com/papers/692509f6c0ce034ddc352c3ahttps://doi.org/10.1038/s41408-025-01391-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A superantigen-based MHC class II-targeted cancer immunotherapy for the treatment of acute myeloid leukemia2025
  2. 2Abstract 5552: MHC class II engager immunotherapy for the treatment of acute myeloid leukemia2026
  3. 3Enhancement of CD117-targeted bispecific T-cell engagement by CD33-targeted bispecific T-cell co-stimulation in acute myeloid leukemia2026
  4. 4Control of acute myeloid leukemia and generation of immune memory in vivo using AMV564, a bivalent bispecific CD33 x CD3 T cell engager2024 · 6 citations
  5. 5The tandem CD33-CLL1 CAR-T as an approach to treat acute myeloid leukemia.2024 · 10 citations