Systematic review reveals antipsychotics disrupt glucose homeostasis in patients, indicating heightened fasting glucose and HbA1C levels.
A systematic review and meta‐analysis has found that antipsychotic exposure is associated with significant disruptions to glucose homeostasis, including increased fasting glucose and glycated hemoglobin (HbA1C) relative to placebo. These dysregulations were observed independently of weight gain and treatment duration, the investigators reported. Results of the systematic review and meta‐analysis were published online Aug. 27, 2025, in JAMA Psychiatry .
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