Persistent Unilateral Scleral Icterus in a Patient with Gilbert Syndrome and Prior Facial Malignancy: A Case Report and Review of the Literature

Unilateral yellow discoloration of the eye, commonly referred to as scleral icterus, is an uncommon clinical finding; there are only 14 cases of persistent unilateral scleral icterus documented in the literature. Here, we describe a patient with Gilbert’s syndrome who presented with left-sided conjunctival and scleral icterus presumed secondary to poor vascular outflow following surgical and radiation treatment of squamous cell carcinoma of the left ear with parotid and cervical lymph node involvement. The current case describes a unique physical finding, reviews the pathophysiology of conjunctival and scleral icterus, and reviews the current literature on this topic.