Observations reveal significant diversity in Mycobacterium tuberculosis sublineages in Pakistan, suggesting a need for specialized diagnostics and treatment.
Collectively, these observations highlight Lineage 3's ability to acquire first-line drug resistance continued transmission. Its predominance in the current study highlights the urgent need for lineage-specific diagnostics, enhanced drug susceptibility testing and tailored therapeutic regimens. The detection of diverse Mtb sublineages, including L3.1.2.1 and various sublineages of L4 (e.g., 4.1.1.1, 4.1.2.1, 4.3.4.2, and 4.6.2.2), signifies advancement in understanding the genetic landscape of TB in the region.
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Khan et al. (2025) studied this question.
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