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November 15, 2025Brain Research BulletinOpen Access

Exploring the toxicological impact of di(2-ethylhexyl) phthalate exposure on Alzheimer's disease via network toxicology and integrative bioinformatics analysis

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Authors

WYWeiqing YangSYSunan YongWZWanjia Zhang

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Overview

Computational biology reveals di(2-ethylhexyl) phthalate's neurotoxic effects in Alzheimer's disease, suggesting risk assessment pathways.

Key Points

  • This research aims to understand how di(2-ethylhexyl) phthalate relates to Alzheimer's disease progression.
  • Employs network toxicology and bioinformatics analysis methods
  • Utilizes machine learning and molecular docking techniques
  • Examines mitochondrial homeostasis and neuronal integrity
  • Identifies neurotoxic pathways linked to di(2-ethylhexyl) phthalate exposure
  • Highlights oxidative stress as a significant contributing factor
  • Establishes groundwork for Alzheimer's disease biomarker identification

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/6925198ec0ce034ddc353508https://doi.org/10.1016/j.brainresbull.2025.111635
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