N-Directed, Co-Catalyzed Functionalization of Distal C(sp 3 )-H Bonds with Phenols: Arylation vs. Aryloxylation

Yu-han Wang; Hai-Tao Qin; Feng Liu

doi:10.1039/d5qo01421b

November 15, 2025Organic Chemistry Frontiers

N-Directed, Co-Catalyzed Functionalization of Distal C(sp 3 )-H Bonds with Phenols: Arylation vs. Aryloxylation

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Key Points

The developed method enhances functionalization of C(sp 3 )-H bonds, driving arylation of phenols effectively.
Key evidence includes the successful regioselective arylation yields under cobalt catalysis in organic synthesis.
Observational analysis of cobalt-catalyzed reactions was utilized to demonstrate the effectiveness of the method.
This approach may enable broader applications in synthetic chemistry for targeted functionalization.

Implication

Cobalt-catalyzed reaction improves regioselective arylation in phenolic compounds, highlighting its potential benefits for organic synthesis.

Abstract

Chemo-and regioselective functionalization of free phenols is a continuing challenge. Herein, cobalt-catalyzed cross-dehydrogenative coupling (CDC) of phenols with distal C(sp 3 )-H bonds is achieved. The reaction exhibits good to...

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Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/6925198ec0ce034ddc353634 https://doi.org/10.1039/d5qo01421b

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N-Directed, Co-Catalyzed Functionalization of Distal C(sp 3 )-H Bonds with Phenols: Arylation vs. Aryloxylation

Key Points

Implication

Abstract

Discussion

Cite This Study

N-Directed, Co-Catalyzed Functionalization of Distal C(sp 3 )-H Bonds with Phenols: Arylation vs. Aryloxylation

Key Points

Implication

Abstract

Discussion

Cite This Study

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