Notum disrupts Wnt/β-catenin-mediated BMP9 osteogenesis in MSCs: implications for bone regeneration

Wen-Ge He; Xin-Yue Wan; Yin-kun Hu; Yu-mei Wang; Zheng Hao Xu; Zhong Gan; Liang Chen; Wen-Ge He; Xin-Yue Wan; Yin-kun Hu; Yu-mei Wang; Zheng Hao Xu; Zhong Gan; Liang Chen

doi:10.1080/03008207.2025.2582827

November 14, 2025Connective Tissue Research

Notum disrupts Wnt/β-catenin-mediated BMP9 osteogenesis in MSCs: implications for bone regeneration

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Key Points

This research aims to explore the role of Notum in BMP9-induced osteogenesis and its implications for bone regeneration.
Investigated the modulation of Wnt/β-catenin signaling by Notum in MSCs.
Assessed BMP9-induced osteogenesis in response to Notum activity.
Notum regulates the Wnt/β-catenin pathway affecting BMP9-mediated osteogenesis.
Findings suggest targeting Notum could enhance bone regeneration strategies.

Implication

Notum disrupts osteogenesis in MSCs via Wnt/β-catenin modulation, indicating its potential as a therapeutic target.

Abstract

NOTUM serves as a novel regulator of BMP9-Induced osteogenesis via modulation of the Wnt/β-Catenin Axis, Suggesting its potential as a therapeutic target for bone regeneration.

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Cite This Study

He et al. (2025) studied this question.

synapsesocial.com/papers/69251999c0ce034ddc3539a0 https://doi.org/10.1080/03008207.2025.2582827

View at Publisher

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Notum disrupts Wnt/β-catenin-mediated BMP9 osteogenesis in MSCs: implications for bone regeneration

Key Points

Implication

Abstract

Discussion

Cite This Study

Notum disrupts Wnt/β-catenin-mediated BMP9 osteogenesis in MSCs: implications for bone regeneration

Key Points

Implication

Abstract

Discussion

Cite This Study

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