Reamer Irrigator Aspirator (Ria) Versus Autogenous Iliac Crest Bone Graft (AIcbg) for the Treatment of Nonunions: A Multicentre Randomized Trial

This is a Human Clinical Trial study (also classified as: Pre-Registered Trial, RCT).

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Key Points

This research investigates the effectiveness of RIA compared to AICBG for treating nonunions.
Conducted a multicentre, randomized control trial across seven Level 1 trauma centres.
Patient eligibility included individuals aged 18-65 with long bone non-unions or bone defects.
Primary outcome was pain at the harvest site, measured by visual analog score.
Secondary outcomes included volume of graft, union rates, reoperation rates, and complications.
Pain at the harvest site was significantly lower in the RIA group one day post-surgery (4.0±2.5 vs 5.5±2.7, p=0.02).
Graft volume obtained was significantly higher in the RIA group (37.8 ml vs 19.3 ml, p<0.01).
Union rates and complications were equivalent between both groups.

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Randomized trial shows RIA bone graft reduces pain and provides larger volumes in nonunions, indicating a viable alternative to AICBG.

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Nauth et al. (2025) studied this question.

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