Experiments demonstrate that membrane depolarization increases cell proliferation in human cells, indicating a role for membrane lipids and ERK signaling.
Key Points
This research explores how membrane potential affects ERK activity and cell proliferation.
Conducted experiments on human cells to assess the impact of membrane depolarization on mitosis.
Analyzed the dependence of ERK activity on membrane potential.
Investigated the role of phosphatidylserine dynamics without calcium influx involvement.
Membrane depolarization was found to promote mitosis in human cells.
ERK activity showed a significant dependence on membrane potential, even at resting levels.
Small shifts in resting membrane potential can influence cell proliferation.