PulseTrendingJournal ClubResearchersJournalsExplore
Instagram
HomeTrendingJournal ClubExplore
Synapse
⌘+K
Synapse
November 13, 2025Biomedicine & PharmacotherapyOpen Access

Targeting PRMT5 in cancer: Mechanistic insights and clinical progress

View Full Paper
Ask AI
Bookmark
Share

Authors

JLJoohyun LeeJKJiye KimIHInah Hwang

Discussion

Loading...

Member takes

Overview

Review uncovers PRMT5's role in malignant transformations like metastasis and therapeutic resistance, suggesting new inhibitors may improve outcomes.

Key Points

  • This review aims to explore the oncogenic functions of PRMT5 and recent therapeutic strategies targeting it.
  • Comprehensive overview of PRMT5's mechanistic role in cancer
  • Analysis of early-generation inhibitors and their limitations
  • Discussion of MTA-cooperative inhibitors for tumor specificity
  • Examination of ongoing investigations into PRMT5 inhibition
  • PRMT5 plays a critical role in transcription, DNA repair, and apoptosis
  • Targeting PRMT5 can potentially overcome therapeutic resistance
  • MTA-cooperative inhibitors show promise in precision oncology
  • Ongoing studies aim to optimize combination strategies for enhanced efficacy

Cite This Study

Lee et al. (2025) studied this question.

synapsesocial.com/papers/692523b2c0ce034ddc3548eehttps://doi.org/10.1016/j.biopha.2025.118754
View Full Paper
Ask AI
Bookmark
Share