Silencing Becn1 improves cardiomyocyte differentiation and lineage commitment, suggesting new regenerative approaches.
Becn1 serves as a negative regulator of cardiac lineage commitment by orchestrating stage-specific Wnt/BMP signaling dynamics. Silencing Becn1 enhances cardiomyocyte differentiation and enables growth factor-independent lineage progression. These findings offer a novel approach to improve the efficiency and scalability of stem cell-derived cardiomyocyte production for regenerative applications.
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Xiang et al. (2025) studied this question.
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