This review demonstrates ghrelin's diverse effects on glucose homeostasis and innate immunity, suggesting therapeutic potential in obesity and inflammatory diseases.
Key Points
This review aims to explore the multifaceted roles of ghrelin in physiology and its therapeutic applications.
Synthesis of current research on ghrelin biogenesis, signaling, and systems biology.
Analysis of recent findings on GHSR1a ligands and synthetic compounds.
Review of ghrelin’s interaction with physiological systems and implications for treatment.
Ghrelin modulates various physiological functions beyond hunger, including glucose homeostasis and innate immunity.
Recent structural studies using cryo-EM reveal insights into GHSR1a and its interactions with ligands.
Ghrelin’s activity suggests its potential as a therapeutic target for obesity and inflammatory diseases.