A case report highlights successful desensitization to liposomal amphotericin B during pregnancy, suggesting effective management of cryptococcosis.
Background Cryptococcosis is the most common opportunistic fungal infection in people with human immunodeficiency virus. On a global scale, it causes 15% of acquired immunodeficiency syndrome-related mortality. Case Summary We report the case of a 21-year-old cisgender pregnant woman living with human immunodeficiency virus who presented with headache and photophobia. Her clinical course was complicated by recurrent hospital admissions for disseminated cryptococcosis and a life-threatening reaction to liposomal amphotericin B, the mainstay of treatment. A desensitization protocol was implemented, allowing for continuation of therapy during pregnancy. Conclusion The management of cryptococcosis in pregnancy is challenging due to the potential teratogenic effects of antifungals used and the limited therapeutic options available. This case highlights the complexities of treatment in pregnancy and demonstrates successful desensitization to liposomal amphotericin B during pregnancy.
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Ajao et al. (2025) studied this question.
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