Mechanistic study reveals radiotherapy could enhance a personalized cancer vaccine using immunogen from tumor cells.
Radiation-elicited tumor cell death exhibited an in situ vaccine effect to potentiate immune checkpoint blockade, and autologous tumor cells irradiated in vitro at a sterilization level may serve as a candidate source of immunogen for personalized therapeutical cancer vaccine.
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Pang et al. (2025) studied this question.
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