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Randomized controlled trial shows Linaclotide plus 2 L-PEG enhances bowel preparation in older adults, suggesting fewer adverse reactions and higher repeat willingness.
The bowel preparation efficacy of Lina + 2 L-PEG is comparable to that of 3 L-PEG, yet superior to that of 2 L-PEG. Moreover, Lina + 2 L-PEG is associated with fewer adverse reactions, a lower cost, and a higher willingness to repeat the colonoscopy among patients aged over 60 years.
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Sun et al. (2025) studied this question.
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