Cirsimaritin demonstrates hepatoprotective effects against CCl4-induced apoptosis in rats, indicating oxidative stress and inflammation may be mitigated.
Cirsimaritin protects against CCl₄-induced hepatotoxicity by enhancing antioxidant defenses, correcting cytokine imbalance, and inhibiting apoptosis, at least partly via activation of Nrf2/HO-1 and suppression of NF-κB signaling. These findings highlight cirsimaritin as a promising natural hepatoprotective candidate.
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Bseiso et al. (2025) studied this question.
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