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Photocatalytic method enhances atom economy and site selectivity in substrates using pyridine N-oxides and N-methylsulfonamides, indicating broad application potential.
This study presents a synergistic photocatalytic method using acridinium salts and pyridine N-oxides for the Giese reaction between N-methylsulfonamides and olefins, which utilizes N-methylsulfonamides as α-aminoalkylating reagents. Notable features of this approach include mild reaction conditions, excellent atom economy, good site selectivity, a broad substrate scope, and the ability to enable postmodification of complex drug fragments.
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Yang et al. (2025) studied this question.
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