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November 11, 2025International Journal of Molecular SciencesOpen Access

The Origins and Genetic Diversity of HIV-1: Evolutionary Insights and Global Health Perspectives

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Authors

IAIvailo AlexievRDReneta Dimitrova

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Overview

Review reveals HIV’s genetic diversity influences treatment strategies in a global pandemic, highlighting needs for tailored therapies.

Key Points

  • The aim is to trace the evolutionary origins and genetic diversity of HIV-1, and its implications for global health.
  • Reviewed evolutionary history of HIV-1 from zoonotic origins to current pandemic status
  • Analyzed phylogenetic relationships and genetic diversity of HIV strains
  • Evaluated interventions including next-generation sequencing for surveillance and broadly neutralizing antibodies for therapy.
  • HIV-1 originated from simian immunodeficiency viruses through cross-species transmission
  • Distinct subtypes of HIV-1 showcase varied epidemiological patterns and drug resistance
  • Next-generation sequencing improves real-time surveillance of mutations and transmission networks.

Cite This Study

Alexiev et al. (2025) studied this question.

synapsesocial.com/papers/69252e90c0ce034ddc35611dhttps://doi.org/10.3390/ijms262210909
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