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November 11, 2025Journal of VirologyOpen Access

Ceramide synthase 4 interferes with replication of influenza virus but is downregulated by infection

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Authors

KJKwang Il JungCXChuan XiaSMSavannah McKenna

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Overview

Investigations show ceramide synthase 4 restricts influenza virus replication in cells, indicating potential for host-targeted therapy.

Key Points

  • This research aims to explore the role of ceramide synthase 4 in regulating influenza virus infection and host defense mechanisms.
  • Studied the effects of ceramide synthase 4 on influenza virus replication in stably expressing and knockdown cell models.
  • Assessed viral protein production and infectious progeny viruses in relation to ceramide synthase 4 levels.
  • Evaluated the impact of ceramide synthase 4 on JNK activation during influenza infection.
  • Ceramide synthase 4 significantly impaired influenza virus replication in expressing cells.
  • Knockdown of ceramide synthase 4 enhanced influenza virus replication.
  • Influenza virus infection led to ceramide synthase 4 downregulation through ubiquitination, reducing its antiviral effects.

Cite This Study

Jung et al. (2025) studied this question.

synapsesocial.com/papers/69252ea3c0ce034ddc3566f0https://doi.org/10.1128/jvi.01563-25
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