Shugan Xiaozhi Decoction attenuates nonalcoholic steatohepatitis by modulating oxidative stress and AMPK pathway

Rong Yang; Lian Feng; Zhijian Gong; Huili Yang; Haiyan Du; Jing Chen; Meirong Qin; Ning Chen; Houshuang Huang; Wang Ping; Qibiao Wu; Yufeng Xing

doi:10.1186/s12906-025-05099-z

November 10, 2025BMC Complementary Medicine and TherapiesOpen Access

Shugan Xiaozhi Decoction attenuates nonalcoholic steatohepatitis by modulating oxidative stress and AMPK pathway

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Key Points

This research investigates the effects of Shugan Xiaozhi Decoction on nonalcoholic steatohepatitis.
Experimental model using HFHC diet to induce NASH in subjects.
Administration of Shugan Xiaozhi Decoction to assess effects on oxidative stress.
Evaluation of the AMPK pathway modulation as a mechanism.
Shugan Xiaozhi Decoction attenuates the severity of nonalcoholic steatohepatitis.
Reduces markers of oxidative stress in the liver tissue.
Indicates a therapeutic potential for managing NASH.

Implication

SX reduces oxidative stress in nonalcoholic steatohepatitis, suggesting therapeutic value for NASH management.

Abstract

SX ameliorates HFHC diet-induced NASH by regulating hepatic oxidative stress and AMPK pathway, suggesting the potential therapeutic value of SX in NASH treatment.

Discussion

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Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/69253a16c0ce034ddc356c17 https://doi.org/10.1186/s12906-025-05099-z

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Shugan Xiaozhi Decoction attenuates nonalcoholic steatohepatitis by modulating oxidative stress and AMPK pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

Shugan Xiaozhi Decoction attenuates nonalcoholic steatohepatitis by modulating oxidative stress and AMPK pathway

Key Points

Implication

Abstract

Discussion

Cite This Study

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