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November 9, 2025BiomoleculesOpen Access

Mitochondrial Dysfunction in Cardiomyopathy and Heart Failure: From Energetic Collapse to Therapeutic Opportunity

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Authors

NPNikola PavlovićPTPetar TodorovicMMMirko Maglica

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Overview

Review demonstrates mitochondrial dysfunction impacts heart failure, suggesting therapeutic strategies may improve outcomes in cardiomyopathy.

Key Points

  • This work synthesizes insights into mitochondrial dysfunction in cardiomyopathy and heart failure and explores therapeutic strategies.
  • Review of current understanding of mitochondrial biology in cardiac health and disease.
  • Examination of diverse cardiomyopathy phenotypes and their associated mitochondrial pathologies.
  • Investigation of emerging therapeutic avenues including SGLT2 inhibition, NAD+ repletion, and mitochondrial transplantation.
  • Mitochondrial dysfunction is a hallmark of cardiomyopathy and heart failure.
  • Therapeutic strategies targeting mitochondrial dysfunction show promise but face clinical translation challenges.
  • Advances in biomarker discovery and personalized medicine may optimize mitochondrial-targeted therapies.

Cite This Study

Pavlović et al. (2025) studied this question.

synapsesocial.com/papers/69253a35c0ce034ddc357a9chttps://doi.org/10.3390/biom15111572
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