PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
November 1, 2025Neuro-Oncology0 citations

Single-Cell Analysis of Tumor Microenvironment and Genotype in Glioblastoma

TMIC-24. Single-cell decoding of the genotype-immunophenotype relationship in glioblastoma

View Full Paper

Authors

NSNishant SoniKRKavita RawatZCZhihong Chen

Discussion

Loading...

Member takes

Overview

Single-cell RNA sequencing reveals tumor heterogeneity in glioblastoma, indicating critical insights for targeted therapies.

Key Points

  • Investigate the relationship between genotype and tumor microenvironment in glioblastoma using single-cell techniques.
  • Conducted single-cell RNA sequencing to characterize mGBM models.
  • Performed multicolor flow cytometry and computational analysis.
  • Compared findings with bulk RNA-seq data from human GBM tumors.
  • PDGFB-driven tumors were more proliferative with enhanced Wnt signaling interactions.
  • EGFRvIII-driven tumors exhibited elevated interferon signaling responses.
  • Nf1-silenced tumors showed higher myeloid abundance and immunosuppressive interactions.
Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Soni et al. (2025) studied this question.

synapsesocial.com/papers/69254362c0ce034ddc358196https://doi.org/10.1093/neuonc/noaf201.1779
Ask AI
Helpful
Bookmark
Share
View Full Paper