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November 1, 2025Neuro-OncologyOpen Access

PATH-78. First Reported Case of MALAT1-GLI Fusion in a Spinal Cord Astrocytoma

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Authors

MAMark AndersonELErnest Lam

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Overview

Case report reveals MALAT1-GLI fusion in a spinal cord anaplastic astrocytoma, highlighting potential therapeutic targets and prognostic markers.

Key Points

  • To report the first known case of MALAT1-GLI fusion in a spinal cord astrocytoma and explore its implications.
  • Case presentation of a 43-year-old male with lower extremity weakness and MRI findings of an intramedullary lesion.
  • Surgical resection and genomic profiling were performed to identify genetic alterations.
  • Conventional radiation therapy and temozolomide were administered.
  • MALAT1-GLI fusion identified, marking it as the first report in spinal cord astrocytoma.
  • Patient has survived 8 years post-treatment with no progression, suggesting a potential prognostic marker.
  • Fusion may indicate aberrant Hedgehog pathway signaling involved in oncogenesis.

Cite This Study

Anderson et al. (2025) studied this question.

synapsesocial.com/papers/69254366c0ce034ddc3583a0https://doi.org/10.1093/neuonc/noaf201.1030
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