Angi-10. The Role of Tsc22 Family Proteins in Glioblastoma Malignancy

Glioblastoma shows the most undifferentiated histopathological cell morphology and is one of the poorest prognosis among human malignant tumors. The main features of glioblastoma include high cell proliferative capacity, diffuse invasiveness, and high angiogenic potential. In this study, we focus on the molecular mechanism of TSC22 family proteins, which are expressed in many glioblastoma cell lines. We investigated the role of TSC22 family proteins in tumors, and found that knockdown of TSC22 family proteins reduced the proliferation, invasion, and sphere-forming ability of glioblastoma cell lines. We also found that phosphorylation modification of TSC22 family proteins increased proliferation, motility, and invasive potential, as well as cancer cell-like morphological changes. These findings suggest that over-activated TSC22 family proteins in glioblastoma cells may contribute to the promotion of tumorigenesis and malignant transformation of cancer. In addition, we would like to report the mechanism by which the molecule of interest contributes to the growth and invasive potential of cancer cells and examine its effectiveness as a therapeutic target.