271 Evaluation of Blood Glucose Measurement in Patients at Risk for Neonatal Hypoglycemia

Introduction/Objective Neonatal hypoglycemia can lead to neurodevelopmental impairment if untreated. In our institution, infants with risk factors are screened for hypoglycemia. Blood glucose levels (BGL) are measured using Point-of-care (POC) Accu-Chek Inform II, with values below 50 mg/dL requiring confirmation via the POC Radiometer ABL90 Flex Plus or Beckman Coulter AU5800. Methods/Case Report This study compares neonatal BGL below 50 mg/dL across these platforms. The results were analyzed using EP Evaluator for Deming regression and Bland-Altman analysis. Results Comparison of BGL (22-50 mg/dL; 54 neonates) between Accu-Chek and ABL90 showed a correlation coefficient (R) of 0.5581, with a slope of 1.664 and a mean bias of 0.1. Comparison of BGL (17-47 mg/dL; 18 neonates) between Accu-Chek and AU5800 showed an R of 0.976, with a slope of 0.968 and mean bias of 2.1. Conclusion For neonatal BGL below 50 mg/dL, the results from Accu-Chek showed a poor correlation with the ABL90 results, while demonstrating a good correlation with the results from AU5800, the standard method. Therefore, neonatal BGLs that are below 50 mg/dL but above the critical value of 40 mg/dL do not necessitate additional confirmation. This approach helps minimize unnecessary sample collections and laboratory testing.