Abstract Introduction/Objective Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary hepatic malignancy accounting for 2-5% of primary liver carcinomas. cHCC-CCA is defined by presence of histologic features of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA). In this submission, we present an interesting case of cHCC-CCA and highlight the important features and significance of correctly diagnosing cHCC-CCA. Methods/Case Report We report an interesting case of cHCC-CCA in a 66-year-old male with a 5 cm targetoid mass in hepatic segment 8, suspicious for an atypical HCC. The patient underwent an image guided liver mass biopsy. H however, collision tumors are not part of this entity. Distant metastasis of this tumor can show either cHCC-CCA features or any individual component of the combined tumor. Correct diagnosis of cHCC-CCA is of utmost importance given that cHCC-CCA has a worse prognosis and different clinical follow-up pattern than a conventional HCC. As cHCC-CCA are treated clinically as a more aggressive tumor along the lines of the CCA component so we should always keep this rare diagnosis in our mind when examining the liver neoplastic biopsies.
Lam et al. (2025) studied this question.