Serum soluble fms-like tyrosine kinase and placental growth factor ratio on Elecsys immunoassay platform predicts preeclampsia with severe features in hospitalized women with hypertensive disorders of pregnancy

Anders H. Berg; Vinicius F. Calsavara; Martin Hund; Guo Ge; Sarosh Rana; Maged M. Costantine; Jimmy Espinoza; Kim Boggess; Blair J Wylie; Tiffany A. Moore-Simas; Judette M Louis; Stephanie L. Gaw; Amy Murtha; Samantha Wiegand; Yvonne G Gollin; Deepjot Singh; Robert M Silver; Danielle E. Durie; Britta Panda; Errol R. Norwitz; Irina Burd; Beth Plunkett; Rachel K Scott; Martha Bautista; Elizabeth Lemoine; Sarah Kilpatrick; Ravi Thadhani; S. Ananth Karumanchi

doi:10.1016/j.ajog.2025.11.006

Key Points

To assess the predictive value of the sFlt-1/PlGF ratio for preeclampsia and related outcomes.
Used Elecsys immunoassay platform to measure sFlt-1/PlGF ratio.
Examined hospitalized preterm pregnant women with hypertensive disorders of pregnancy (HDP).
Predicted outcomes within two weeks of testing.
The sFlt-1/PlGF ratio >38 was predictive of severe preeclampsia (sPE).
Associated with delivery and adverse maternal and fetal/neonatal outcomes.

Implication

Predictive sFlt-1/PlGF ratio indicates risks of severe preeclampsia and related outcomes in hypertensive pregnant women.

Abstract

The sFlt-1/PlGF ratio >38 measured on the Elecsys platform predicted the development of sPE, delivery, and adverse maternal and fetal/neonatal outcomes within two weeks of testing among preterm pregnant women hospitalized with HDP. (Funded by Cedars-Sinai Medical Center and Roche Diagnostics).

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Cite This Study

Berg et al. (2025) studied this question.

synapsesocial.com/papers/69254371c0ce034ddc35896a https://doi.org/10.1016/j.ajog.2025.11.006

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Serum soluble fms-like tyrosine kinase and placental growth factor ratio on Elecsys immunoassay platform predicts preeclampsia with severe features in hospitalized women with hypertensive disorders of pregnancy

Key Points

Implication

Abstract

Discussion

Cite This Study

Serum soluble fms-like tyrosine kinase and placental growth factor ratio on Elecsys immunoassay platform predicts preeclampsia with severe features in hospitalized women with hypertensive disorders of pregnancy

Key Points

Implication

Abstract

Discussion

Cite This Study

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