This study demonstrates differing rates of functional decline in RPGR phenotypes, implying microperimetry's value as an outcome measure.
This study reveals significantly different rates of functional decline between RPGR phenotypes, with CORD patients at markedly higher risk of early central vision loss. These findings support the use of microperimetry as a sensitive outcome measure and provide critical survival data for clinical trial design, patient counselling, and therapeutic prioritization. Patients with cone-dominated phenotypes may benefit from earlier intervention.
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Josan et al. (2025) studied this question.
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