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November 1, 2025Journal of the American Academy of DermatologyOpen Access

Population differences in Merkel cell carcinoma by virus status and anatomic site: A multi-cohort analysis including institutional, SEER, and NCDB data

Mackenzie R Martin Serena M. Vilasi Yoshine Saito Noreen Mohsin Jordan E Jarvis Patrick Hallaert Danielle J. Reed Lingling Miao Jacob T. Tribble Elizabeth K. Cahoon Ruth M. Pfeiffer Krista Lachance Rima Kulikauskas Paul Nghiem Isaac Brownell

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Key Points

To investigate population differences in Merkel cell carcinoma (MCC) related to virus status and the anatomic site of lesions.
Multi-cohort analysis involving institutional, SEER, and NCDB data.
Comparison of MCC development across racial groups, specifically Black and Hispanic patients.
Examination of outcomes based on site and virus association.
Black and Hispanic patients develop MCC more frequently on UV-protected sites.
Virus-positive Merkel cell carcinoma (VP-MCC) is more common in these populations.
VP-MCC is associated with improved patient outcomes.

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Implication

Multi-cohort analysis shows virus-associated outcomes in Merkel cell carcinoma across diverse populations.

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Cite This Study

Martin et al. (2025) studied this question.

synapsesocial.com/papers/6925437fc0ce034ddc358ea8 https://doi.org/10.1016/j.jaad.2025.11.023

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