Case report demonstrates a mucous gland adenoma in a 60-year-old male, highlighting nkx3.1 as a diagnostic marker and absence of recurrence post-surgery.
Mucous gland adenoma (MGA) is a rare, benign lung tumour. Recently, NKX3.1 immunohistochemistry was reported to be a diagnostic marker for distinguishing MGA from other mucinous tumours. A 60‐year‐old male with a 20‐year history of a tumor‐like lesion, primarily composed of mucus in the left lingual region. While the lesion was being monitored, its size gradually increased. We then performed a segmentectomy of the lingula. Postoperative pathological examination showed that the tumour had a tubulopapillary structure. The tumour cells were columnar with slight atypia, diffusely positive for NKX3.1 and were diagnosed as MGA. No recurrence was found after 6 months of postoperative follow‐up, and the sputum count had markedly decreased. This case report aids in elucidating the pathogenesis of MGA and NKX3.1‐positive lung tumours.
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Ishii et al. (2025) studied this question.
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