Forum article discusses unresolved issues in auxin signaling and the role of cyclic AMP as a second messenger in plants.
The canonical mechanism by which the phytohormone auxin regulates transcription has been one of the cornerstones of plant signaling. The recent unexpected discovery of cyclic AMP (cAMP) as a second messenger in this pathway has revised its foundations while leaving many open questions and gaps in our understanding; these will be discussed in this forum article.
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Jiří Friml (2025) studied this question.
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