Whole-Genome Analysis of qacA-Harboring ST45-SCCmec Vc-t1081 MRSA from Skin Exudate in a Chinese Patient with Severe Drug Eruption

Wei Kong; Qinghuan Zhang; Limei Zhang; Jing Yang; Xiaobin Li; Yanyan Liao

doi:10.1016/j.jgar.2025.11.008

November 1, 2025Journal of Global Antimicrobial ResistanceOpen Access

Whole-Genome Analysis of qacA-Harboring ST45-SCCmec Vc-t1081 MRSA from Skin Exudate in a Chinese Patient with Severe Drug Eruption

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Key Points

To analyze the genome of a qacA-harboring MRSA strain and assess its antimicrobial resistance.
Conducted whole-genome sequencing of MRSA strain SA0907.
Identified a 2.46-kb erm(C)-harboring plasmid pSA0907-2.
Analyzed genomic features of ST45-SCCmec Vc-t1081 MRSA in skin exudate from a Chinese patient.
Reported the first complete genome of qacA-harboring ST45-SCCmec Vc-t1081 MRSA in China.
Found a widely present erm(C)-harboring plasmid in S. aureus and other staphylococci.
Observed significant antimicrobial resistance implications of the strain.

Implication

Genomic analysis reveals qacA-harboring MRSA and significant drug resistance in Staphylococcus aureus from skin exudate.

Abstract

MRSA strain SA0907 represents the first complete genome report of a qacA-harboring ST45-SCCmec Vc-t1081 MRSA in Mainland of China. One 2.46-kb erm(C)-harboring plasmid pSA0907-2 carried by the MRSA strain SA0907 was widely present in S. aureus and other staphylococci.

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Cite This Study

Kong et al. (2025) studied this question.

synapsesocial.com/papers/69254f7dc0ce034ddc359030 https://doi.org/10.1016/j.jgar.2025.11.008

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Whole-Genome Analysis of qacA-Harboring ST45-SCCmec Vc-t1081 MRSA from Skin Exudate in a Chinese Patient with Severe Drug Eruption

Key Points

Implication

Abstract

Discussion

Cite This Study

Whole-Genome Analysis of qacA-Harboring ST45-SCCmec Vc-t1081 MRSA from Skin Exudate in a Chinese Patient with Severe Drug Eruption

Key Points

Implication

Abstract

Discussion

Cite This Study

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