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RE-Aging reveals gene annotation and RNA editing patterns in blood cells, suggesting insights into aging mechanisms.
RNA editing alters mRNA sequences and is linked to aging. We introduce RE-Aging, a platform analyzing age-related RNA editing using GTEx data (259,620 A-to-I and 30,502 C-to-U sites across 27 tissues). Features include site exploration, age correlations, gene annotation, RNA structure analysis, and miRNA binding impact. Supports differential editing analysis (Wilcoxon test) and single-cell RNA editing age mapping for blood cells. Access at http://bioinfo-sysu.com/RE-Aging/.
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Pan et al. (2025) studied this question.
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