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Experimental findings show dietary cysteine improves tissue regeneration in intestinal stem cells, suggesting a crucial metabolism-immune link.
Chi and colleagues revealed that dietary cysteine enhances intestinal stem cell (ISC) regeneration, driving coenzyme A (CoA) synthesis and expansion of intraepithelial (IEL) CD8αβ⁺ T cells that secrete IL-22. This epithelial-immune crosstalk potentiates ISC repair after injury, highlighting a metabolism-immune axis linking cysteine sensing to tissue regeneration.
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Siracusa et al. (2025) studied this question.
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