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November 1, 2025HLAOpen Access

HLA‐DPA1*01:228 is the First DPB1 Allele Described With an Alanine at Position 42 of Alpha‐1 Domain

Luis Alberto Marín‐Rubio Jesús Ontañón

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Key Points

To present and describe the unique allele HLA-DPA1*01:228.
Identification of HLA-DPA1*01:228 allele
Position analysis of amino acids within the alpha-1 domain.
HLA-DPA1*01:228 is characterized by an alanine at position 42
This is the first documented instance of this specific allele.

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Implication

Newly identified HLA-DPA1*01:228 shows an alanine at position 42, suggesting unique properties in HLA biology.

Abstract

HLA‐DPA1*01:228 shows an alanine at position 42 not described previously.

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Cite This Study

Marín‐Rubio et al. (2025) studied this question.

synapsesocial.com/papers/69254f7dc0ce034ddc359225 https://doi.org/10.1111/tan.70450

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Identification of a Novel <scp>HLA</scp> ‐ <scp>DPA1</scp> Allele With a New Amino Acid Residue in the Core Domain, <i>HLA‐DPA1*01:249</i>Original Research · 2026 · 2 citations
2<i>HLA‐DQA1*05:115</i>, the first <scp>DQA1</scp> allele described with an alanine at position 59 of alpha‐1 domain2024 · 3 citations
3Identification of Two New <scp>HLA</scp> ‐ <scp>DPA1</scp> Alleles: <i>HLA‐DPA1*01:248</i> and ‐ <i>DPA1*02:01:41</i>Original Research · 2026 · 2 citations
4Identification of a Novel <scp>HLA</scp> ‐ <scp>DPA1</scp> Allele, <i>HLA‐DPA1*02:162</i> , Using <scp>PolyseqOne</scp> and Oxford Nanopore SequencingOriginal Research · 2026 · 1 citations
5Identification of the novel <scp><i>HLA‐DPA1*01:195</i></scp> allele by next‐generation sequencing2024 · 3 citations

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