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November 1, 2025The Journal of ImmunologyOpen Access

Targeting mucosal associated invariant T (MAIT) cells via the gut microbiome as a novel immunotherapy for pancreatic cancer liver metastasis 4562

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Authors

QMQing-Sheng MiJTJugmohit ToorKSKalpana Subedi

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Overview

Novel immunotherapy demonstrates reduced tumor burden in pancreatic cancer liver metastasis, indicating gut microbiome's role in tumor immunity.

Key Points

  • To evaluate the role of the gut microbiome in modulating MAIT cell dysfunction and tumor burden in pancreatic cancer liver metastasis.
  • Utilized a hemispleen injection model of pancreatic cancer liver metastasis (PCLM).
  • Examined the expression of MR1 in the tumor microenvironment and its effects on MAIT cells.
  • Compared tumor burden in MR1 KO and MR1 WT mice, and assessed effects of antibiotic treatment on the gut microbiome.
  • MR1 is enriched in the tumor microenvironment, promoting MAIT cell dysfunction.
  • MR1 KO mice had significantly reduced tumor burden compared to WT mice.
  • Antibiotic-treated mice showed reduced tumor burden and a shift of MAIT cells from pro- to anti-tumor phenotypes.

Cite This Study

Mi et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3598a7https://doi.org/10.1093/jimmun/vkaf283.2231
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 1590: The role of mucosal associated invariant T (MAIT) cells in pancreatic cancer liver metastasis2024
  2. 2Abstract 6689: Modulation of MAITs by the tumor microbiome in anti-PD1 treated cancers2024
  3. 3Mucosal-associated invariant T cells promote PDAC progression via TL1A–CSF-1 axis2026
  4. 4MR1-driven activation of MAIT cells orchestrates anti-tumor immunity in melanoma 23098302026
  5. 5Adoptive MAIT cell therapy for liver cancer enhanced by multimodal modulation of immune receptors and checkpoints2026